Can Peptides Be used with Tretinoin?

Can Peptides Be used with Tretinoin?

Peptides and tretinoin are two skincare ingredients that deliver quite impactful results but have not really got much understanding behind them. But just because they don’t have the same status or household name as the likes of, glycolic acid, hyaluronic acid, or retinol, you’ll still be so impressed with their benefits and how effective they are in your skincare routine.

What are Peptides?

Naturally occurring in the body, peptides are strings of amino acids which make up the building blocks of protein in the skin surface. When formulated for skincare products these synthetic peptides are cell communicating, meaning they can tell the cells in the lower layers of the skin to boost the production of collagen. This in time leads to a plumped, youthful complexion with visibly reduced signs of ageing. Don’t forget you can find out more about peptides on The Beauty Insiders blog.

What is Tretinoin?

Tretinoin, also known as all-trans retinoic acid and is a prescription skin ingredient. First used to help combat severe acne and frequent breakouts, since then it is also used to target signs of hyperpigmentation, such as sun damage and post acne scarring as well as premature ageing with fine lines and wrinkles notably reduced. Due to the potency of this ingredient, it is strongly advised that you introduce into your everyday skincare routine once you are given the green light from a medical professional. If you are wanting to know more about tretinoin and its benefits check out our dedicated blog post.

So, now you have a better understanding of what these ingredients do, we are now going to investigate whether peptides can be used with tretinoin.

Do peptides work with tretinoin?

Yes, it is generally considered that peptides work with tretinoin because of the fact they effectively work with other forms of retinol. I suggest using this powerhouse duo during your evening routine to avoid any excessive exposure to UV damage. Firstly, apply your tretinoin enriched product, especially if it is a serum as this will rid the surface of dead skin cells and debris. Follow this with your peptide product as this will penetrate the skin quickly and effectively.

Much like all potent skin ingredients it is important to ensure your skin is happy and able to build its tolerance so always ensure you consult with a doctor before applying anything new to your face.

Can tretinoin and copper peptides be used together?

No, it is considered best to avoid using copper peptides and tretinoin together. Copper peptides increase the blood flow for the skin which often leads to any minor damage to the skin becoming easily increased. Combining this with the common side effect of redness and flushing to the skin that comes from using any form of retinol. By using these together you’ll find they increase skin sensitivity and result in all many of skin irritation. Therefore it is best to avoid layering these ingredients, but you can alternate the time of day you apply them to the face, for example, copper peptides during the morning and tretinoin in the evening.

What can you not mix tretinoin?

It is very important to not apply any other potent acne fighting ingredients to the skin when you are already using tretinoin. These ingredients are, salicylic acid, benzoyl peroxide, sulfur and other forms of retinol. This will lead to severe skin irritation, redness, dryness as well as other side effects. If you have any worries or concerns with using your skincare products consult with your doctor or dermatologist for peace of mind.

What is tretinoin vs retinol?

Tretinoin and retinol each provide similar and effective skin benefits as each other. The main difference you can expect is the level of strength and potency found in skincare formulations. Tretinoin is a prescription only ingredient and is pure retinoic acid meaning it is highly potent. Retinol can also be potent but is also a lot more manageable to introduce into your skincare routine. This is because retinol can not only be prescribed, but also found in over the counter formulations containing lower percentages of active levels of retinoids.

What should you not use peptides with?

Copper peptides contain a great selection of benefits for the hair and skin resulting in their popularity increasing rapidly in recent years, here are some of the main benefits:

Increased blood circulation boosts hair growth by stimulating hair follicles

Boost of collagen production reduces the appearance of fine lines and wrinkles

Skin firmness is improved thanks to the collagen and elastin production increased

Antioxidant benefits help protect the skin from daily exposure to free radical damage

The skin tone becomes more even with dark spots, acne scarring, and pigmentation reduced, and skin surface repaired

When it comes to layering peptides with other effective skin ingredients there are some popular ones that should be avoided.


Retinol Tretinoin Vitamin C AHAs/ BHAs such as glycolic acid and salicylic acid Are peptides good for wrinkles? Absolutely! Peptides are highly effective at reducing the appearance of fine lines, wrinkles, and loss of firmness to the skin. As I have already mentioned, peptides act as building blocks for the collagen and elastin found in the lower layers of the skin. By boosting the production of collagen, you are left with a plumped, smoother complexion that has a youthful bounce. Can I use peptides in the morning? Yes, you can indeed! Applying peptides in the morning will boost collagen and increase blood flow giving you an all over improved, healthy, and vibrant skin. You can also use peptides twice a day in both morning and evening routines for maximum results, just if you alternate applying tretinoin to avoid unwanted irritation. Do peptides tighten skin? Yes, they do! This is because peptides have the ability to stimulate the production of collagen you will find the overall look and feel of the skin will improve. Signs of loose skin, lack of elasticity and reduced skin firmness are all combated with regular application of products enriched with peptides. I hope that is answers your questions about peptides and tretinoin, but don’t forget if you have any concerns come and follow us on Instagram, you’ll find me there!

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